Basic Information
VIS ID
TVIS44009943
Fusion event
HTLV-1-MAGI1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
65410657/65424982 (Hg38)
End
65410657/65424982 (Hg38)
Orient
+
Location type
Intronic
Target gene
MAGI1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-34a-5p ; hsa-mir-24-3p ; hsa-mir-324-3p
Nearest miRNA
hsa-let-7g/Upstream/4807112; hsa-mir-12124/Downstream/1800482;
Nearest TSS
ENST00000440867/Upstream/23278; ENST00000472514/Downstream/23255;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/45396, chr3-CpG: 69/Downstream/124027
Upstream sequence
acacagtgagaccctgtctctacaaaacaattttttaaaagagattagcctcacaagatggcacatgcctgtagtcctagctattcaggaggctaaggca
Downstream sequence
ggaggttcatttaagcccaggagtttgaggttgtgatgggccatgatcatgcactccagcctgggcaaaagagcaggaccctgtatcaagagaagaagaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate