Basic Information
VIS ID
TVIS44009953
Fusion event
HTLV-1-C15orf41 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
37052587/36760386 (Hg38)
End
37052587/36760386 (Hg38)
Orient
+
Location type
Intronic
Target gene
C15orf41
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-17-5p ; hsa-mir-574-5p ; hsa-mir-340-5p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-3713 ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-4742-5p ; hsa-mir-5586-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-595 ; hsa-mir-4796-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-548ah-5p ; hsa-mir-3609
Nearest miRNA
hsa-mir-1233-1/Upstream/833463; hsa-mir-10393/Downstream/212435;
Nearest TSS
ENST00000557528/Upstream/4441; ENST00000559509/Downstream/134892;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/180690, chr15-CpG: 36/Downstream/57774
Upstream sequence
CTGTCTTGTAAAATCTGTGTTATAAATGCATAAAGCTGTGGCACCTGTGTTTTCTGCACCATGATGTGACTTTTGTGATAATTCTGTTTTTTCCTTTTAA
Downstream sequence
TATTCAACTAAAAGAACTGTTTTCATGATGCCAAGACATTTTCATTTATCCAGTTGTCTAGTAACCTAAAACAAACAGAAACAAAGGTAGCTTGCACATA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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