Basic Information
VIS ID
TVIS44009962
Fusion event
HTLV-1-BMERB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
15560533/15466676 (Hg38)
End
15560533/15466676 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16A
Target gene
BMERB1
miRNAs that regulate target gene
hsa-mir-1283 ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-106a-3p ; hsa-mir-6879-3p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-564 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-3194-3p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-500b-3p ; hsa-mir-183-5p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-5197-5p
Nearest miRNA
hsa-mir-1225/Upstream/311674; hsa-mir-11401/Downstream/144354;
Nearest TSS
ENST00000527434/Upstream/32088; ENST00000563380/Downstream/35590;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/31447, chr16-CpG: 43/Downstream/176273
Upstream sequence
aatacagagatctatgtatgcctttcacccattttaccccaatggtgacattttggacagctaaatacagtatcaaagacaggaaattgacattgataca
Downstream sequence
atccattcatcctattcagatttcaccagatttatgtgtgtgtctgtgtgtgtgtgtgtgtgtatttagttctatacaattttatcatatatttagattt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate