Basic Information
VIS ID
TVIS44009971
Fusion event
HTLV-1-ZNF34 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
146004002/144778617 (Hg38)
End
146004002/144778617 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
ZNF34
miRNAs that regulate target gene
hsa-mir-3162-5p ; hsa-mir-625-5p ; hsa-mir-6878-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-5093 ; hsa-mir-6770-5p ; hsa-mir-3179 ; hsa-mir-4530 ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6760-5p ; hsa-mir-3154 ; hsa-mir-634 ; hsa-mir-3646 ; hsa-mir-384 ; hsa-mir-7975 ; hsa-mir-5571-3p ; hsa-mir-4326 ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-6878-3p ; hsa-mir-640 ; hsa-mir-378a-5p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3663-5p ; hsa-mir-3653-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-373-5p ; hsa-mir-616-5p ; hsa-mir-371b-5p ; hsa-mir-212-5p ; hsa-mir-1224-3p ; hsa-mir-6513-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-6813-3p ; hsa-mir-6131 ; hsa-mir-215-3p ; hsa-mir-3135b ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-500b-3p ; hsa-mir-5693 ; hsa-mir-6773-3p ; hsa-mir-6812-3p ; hsa-mir-6879-3p ; hsa-mir-891a-3p
Nearest miRNA
hsa-mir-10400/Upstream/316078; hsa-mir-6850/Downstream/13314;
Nearest TSS
ENST00000518652/Upstream/22200; ENST00000528012/Downstream/1665;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/22768, chr8-CpG: 81/Downstream/8188
Upstream sequence
CTGAGGAGCTGAGGGAAGAGAACGCAACAAGTGGAGGCCCAGTCTGGCCCCTTCTTCCACAGCTCAGGCTACTTGGTGCTGCCATAAACAGCCCTGCCTG
Downstream sequence
CCTCACTGGTCCACCCCTGCCCATCCCAATGTGGGTACTGCTAGCTGGCCTCCCGGACATAGACTCCACTCTTTGCCTGGGGCTGCCCTCTCCAGCTCCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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