Basic Information
VIS ID
TVIS44009972
Fusion event
HTLV-1-RAB9B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
103065931/103811001 (Hg38)
End
103065931/103811001 (Hg38)
Orient
-
Location type
Intronic
Target gene
RAB9B
miRNAs that regulate target gene
hsa-mir-224-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-2681-5p ; hsa-mir-372-5p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-380-3p ; hsa-mir-888-5p ; hsa-mir-4775 ; hsa-mir-590-3p
Nearest miRNA
hsa-let-7f-2/Upstream/8747775; hsa-mir-105-1/Downstream/2828813;
Nearest TSS
ENST00000429181/Upstream/22094; ENST00000455723/Downstream/21227;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/123443, chrX-CpG: 66/Downstream/107558
Nearby gene
RAB9B(-11324) ;
Upstream sequence
gggacttaaatatgtcatatttcactgaaaaacctggggatatttcaagttataaaaatcatgtccaggagggaaagaactgtctttagttatcggaagt
Downstream sequence
cctgtgtcatgtggaatccttgttttgagtggccctaggaccaaggagtggaagtcataagaagtcagaatttactcaatataagggatcatgtgccatt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate