Basic Information
VIS ID
TVIS44009974
Fusion event
HTLV-1-ZNF532 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
56650456/58983224 (Hg38)
End
56650456/58983224 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
ZNF532
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-302a-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-302d-3p ; hsa-mir-372-3p ; hsa-mir-373-3p ; hsa-mir-20b-5p ; hsa-mir-520e ; hsa-mir-520a-3p ; hsa-mir-526b-3p ; hsa-mir-520b ; hsa-mir-520c-3p ; hsa-mir-519d-3p ; hsa-mir-520d-3p ; hsa-mir-302e ; hsa-mir-494-3p ; hsa-mir-5580-3p ; hsa-mir-106a-3p ; hsa-mir-4672 ; hsa-mir-3937 ; hsa-mir-6768-5p
Nearest miRNA
hsa-mir-1-2/Upstream/532066; hsa-mir-5011/Downstream/8098360;
Nearest TSS
ENST00000575820/Upstream/3657; ENST00000591900/Downstream/98700;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/119109, chr18-CpG: 69/Downstream/156152
Upstream sequence
GTGTGTGCAAAGGTAGCTTCAGGTCATGGCCACGTGTGAAGGTGCACATGAACAGAGCAGAAAAGCTGGGGCACAGAGTGCGGAGAGGAGGGGCACGTTG
Downstream sequence
GCTTGGGGAGGGGATTCAGAGTGGGATTTAGAGCCCTGGAAGCAGACGCAGTAGGGGAAATGGTGTGAAGGTGAGGAGGCAGGAAAGGGTGGGGAAAGCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate