Basic Information
VIS ID
TVIS44009989
Fusion event
HTLV-1-AMMECR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q23
Reference genome
GRCh37/hg19
Start
109556356/110313128 (Hg38)
End
109556356/110313128 (Hg38)
Orient
-
Location type
Intronic
Target gene
AMMECR1
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-let-7a-5p ; hsa-mir-375 ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-181a-5p ; hsa-mir-192-5p ; hsa-mir-10b-3p ; hsa-mir-92a-3p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p
Nearest miRNA
hsa-let-7f-2/Upstream/230910; hsa-mir-105-1/Downstream/2467590;
Nearest TSS
ENST00000429181/Upstream/168273; ENST00000520821/Downstream/4628;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/309683, chrX-CpG: 83/Downstream/4347
Upstream sequence
TTTAATATCATTTTAACCTGAGCAGCACTATCAAATCATCTTTTTGATAATGCAATAGGATTGCCACAGTTCTGTTGAAACAAAATGCCTACTCCCCAAC
Downstream sequence
ACAACCCAATTCCTCCCAAGCACACTGAAAAACAGCAACTTGACTACGGTGGCAAGACGAGAAAGAGTTAACTGTTAAAACACCTCTTCAGAGTCTCAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate