Basic Information
VIS ID
TVIS44009990
Fusion event
HTLV-1-ZCCHC24 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
81158275/79398519 (Hg38)
End
81158275/79398519 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
ZCCHC24
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-335-5p ; hsa-mir-1301-3p ; hsa-mir-744-5p ; hsa-mir-346 ; hsa-mir-4446-5p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-29a-5p ; hsa-mir-3920 ; hsa-mir-629-3p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-7106-5p ; hsa-mir-149-3p ; hsa-mir-3192-5p ; hsa-mir-2116-3p ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-1224-3p ; hsa-mir-6765-3p ; hsa-mir-7851-3p ; hsa-mir-4290 ; hsa-mir-1233-3p ; hsa-mir-4687-5p ; hsa-mir-335-3p ; hsa-mir-5096 ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-623 ; hsa-mir-6832-3p ; hsa-mir-3938 ; hsa-mir-3936 ; hsa-mir-211-5p ; hsa-mir-204-5p
Nearest miRNA
hsa-mir-1265/Upstream/3845966; hsa-mir-107/Downstream/6866175;
Nearest TSS
ENST00000439456/Upstream/16191; ENST00000520547/Downstream/45700;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/12078, chr10-CpG: 112/Downstream/46177
Upstream sequence
gtgctcggtcaccattagctattTCAGGGTGATTCTCTTCTTCGTTGCCTGCACTAGGAGAGGGAGCAGAGGTGTCTGAGGTATTGCCGAGGCTAGGGCT
Downstream sequence
GAGGTCCACAGGCATTAGTCCCAGGAGGATGGTTCCAGAGATGGGAGGGAAACCTGGGAGGGATATCTGGGTAGCTCTCTATCCCTGGGTAGGAATGGAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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