Basic Information
VIS ID
TVIS44009994
Fusion event
HTLV-1-OTOG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
17663152/17641605 (Hg38)
End
17663152/17641605 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
OTOG
miRNAs that regulate target gene
hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-183-3p ; hsa-mir-1200 ; hsa-mir-378a-5p ; hsa-mir-3124-3p ; hsa-mir-4680-3p ; hsa-mir-3140-5p ; hsa-mir-501-5p ; hsa-mir-500a-5p
Nearest miRNA
hsa-mir-210/Upstream/1671984; hsa-let-7a-2/Downstream/746182;
Nearest TSS
ENST00000527297/Upstream/63341; ENST00000524479/Downstream/53417;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/97100, chr11-CpG: 56/Downstream/54115
Upstream sequence
tttttcagaggagaaaactgaggcttagggagactctgtcatttgtcaaaagtcctacaggaactaagactcaaatggaggtctgtctgGAATAAAAACT
Downstream sequence
GGCATCCTTACTTAGCAGAAATGGCTTGGAAAGGGTGGAGATGCTCTTTGCTGTAAGGGAGGCTCAGGGTAGATACAGGGATGATTAGCTGCCTGTGACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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