Basic Information
VIS ID
TVIS44009997
Fusion event
HTLV-1-EGLN3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
34416429/33947223 (Hg38)
End
34416429/33947223 (Hg38)
Orient
-
Location type
Intronic
Target gene
EGLN3
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-20a-5p ; hsa-mir-130b-3p ; hsa-mir-98-5p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-18a-3p ; hsa-let-7i-5p ; hsa-mir-23a-3p ; hsa-mir-1298-5p ; hsa-mir-6853-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-519d-3p ; hsa-mir-17-5p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-301b-3p ; hsa-mir-130a-3p ; hsa-mir-301a-3p ; hsa-mir-454-3p ; hsa-mir-642a-5p ; hsa-mir-4655-3p ; hsa-mir-6803-3p ; hsa-mir-873-5p ; hsa-mir-4762-5p ; hsa-mir-3938
Nearest miRNA
hsa-mir-208a/Upstream/2932481; hsa-mir-1185-1/Downstream/3005086;
Nearest TSS
ENST00000550708/Upstream/15887; ENST00000555922/Downstream/3603;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/145991, chr14-CpG: 98/Downstream/3079
Nearest cancer related gene
EGLN3(TSG, No orient, 0)
Upstream sequence
AAAAATTATACATTCTCTGGAAAACAGCCATTTTCAAGATCTAGGCAGCCAAAGAAAAAGGAGCAAATTATGACCAATATTTATCTTGGATATGGTCTAA
Downstream sequence
AATCTCCAAAAGGGAGTAGCGAGCGGATAAATCCTTTGCTAGCCTGAAAGCAATGATCATGCTTGAAGTTAGGGGGGGCCATACAGCTGTACATTACAGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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