Basic Information
VIS ID
TVIS44010016
Fusion event
HTLV-1-IFT81 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.11
Reference genome
GRCh37/hg19
Start
110587376/110149571 (Hg38)
End
110587376/110149571 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
IFT81
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7i/Upstream/316135; hsa-mir-1178/Downstream/1154571;
Nearest TSS
ENST00000382841/Upstream/12764; ENST00000551055/Downstream/22324;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/24676, chr12-CpG: 183/Downstream/131016
Upstream sequence
gctcaattagacccctaccttatcacaaggacagagggctttctgtatccctggggttcttgtcttggtgtaccggaagaacggatcacatgtgctcttg
Downstream sequence
gagaatgggtgtaaggttttatggaagtagctttcagcagataggggagcccgaagggagatggttttcccttggagtcaggccgccgagtggcctgact
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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