Basic Information
VIS ID
TVIS44010018
Fusion event
HTLV-1-DIPK1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
93365162/92899605 (Hg38)
End
93365162/92899605 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
DIPK1A
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-98-5p ; hsa-mir-27a-3p ; hsa-mir-101-3p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-545-5p ; hsa-mir-144-3p ; hsa-mir-1273d ; hsa-mir-497-3p
Nearest miRNA
hsa-mir-101-1/Upstream/6541918; hsa-mir-11399/Downstream/947227;
Nearest TSS
ENST00000473358/Upstream/22455; ENST00000474314/Downstream/61895;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/67040, chr1-CpG: 135/Downstream/61350
Upstream sequence
gtctatactttttaagtgggggatttaatctatttctcttaaagcttattattgataggggaaaactcgcttcttcattttattaattgttttctgcttg
Downstream sequence
ttttgtatatcctttgttccttttccttttttcctctcttaatgtttatcattgtcatttggtggtattttgtagtgctatggtttgattcttttcttgt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate