Basic Information
VIS ID
TVIS44010033
Fusion event
HTLV-1-SEMA5A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
9133668/9133556 (Hg38)
End
9133668/9133556 (Hg38)
Orient
+
Location type
Intronic
Target gene
SEMA5A
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-218-5p ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-100-3p ; hsa-mir-4270 ; hsa-mir-4709-3p ; hsa-mir-4645-3p ; hsa-mir-3185 ; hsa-mir-144-3p ; hsa-mir-8077 ; hsa-mir-496 ; hsa-mir-216a-5p ; hsa-mir-548c-3p ; hsa-mir-4695-3p ; hsa-mir-4772-3p ; hsa-mir-6787-3p ; hsa-mir-1304-3p ; hsa-mir-660-3p ; hsa-mir-6736-3p ; hsa-mir-6890-3p ; hsa-mir-4714-3p
Nearest miRNA
hsa-mir-4277/Upstream/79661; hsa-mir-10397/Downstream/1268808;
Nearest TSS
ENST00000502646/Upstream/131782; ENST00000511310/Downstream/131989;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/675396, chr5-CpG: 138/Downstream/411024
Upstream sequence
TATGTGATAAAATACATTGGGTGGGATGACAGACATAGTTTTGTGTAATGAAATACCCTGTCATCAGAAGAAGCAGACCTTGTAATGAGTGTTTTGCTGA
Downstream sequence
CTGAGAGCCAGATATCACATCTCAGCTTTATTTTTGAAAGCAGAGATGGTAGAGGAGGCAGCCTTGACACCATGGCAGATCCTTGTTACCTTCTGATCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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