Basic Information
VIS ID
TVIS44010044
Fusion event
HTLV-1-HS2ST1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
87492514/87026831 (Hg38)
End
87492514/87026831 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
HS2ST1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-let-7b-5p ; hsa-mir-5011-5p ; hsa-mir-651-3p ; hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-205-3p ; hsa-mir-4531 ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-4328 ; hsa-mir-8084 ; hsa-mir-1273d ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p
Nearest miRNA
hsa-mir-101-1/Upstream/669144; hsa-mir-11399/Downstream/6820001;
Nearest TSS
ENST00000473358/Upstream/33822; ENST00000619924/Downstream/102934;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/111300, chr1-CpG: 78/Downstream/105029
Upstream sequence
CTACAGCCTCTGGATGAATGGCAACATAAAACTAGGGTCTTCAATTACCAGCTTAAAAAAAGAAGATATTAAATATAAATATCAGAAAACTTGATTATAA
Downstream sequence
ACACTATTGATGGGAAGAAAAAAAAACTTGATTAAAATATCCTGAATTGTAAGGGGACCCATTCATTAAGATATTGATTATAATAGTGAAATTTAAAGTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate