Basic Information
VIS ID
TVIS44010046
Fusion event
HTLV-1-chr6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
144386210/144065073 (Hg38)
End
144386210/144065073 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/3381190; hsa-mir-1202/Downstream/7037602;
Nearest TSS
ENST00000381078/Upstream/474; ENST00000367568/Downstream/30500;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/322, chr6-CpG: 51/Downstream/30009
Nearby gene
PLAGL1(-474) ;
Nearest cancer related gene
PLAGL1(TSG, -474) ;
Upstream sequence
ataaaatgagattctgggattagcaagcatctgtgcgcgtgagggggcccgaagcttaagcttcattagcttcacgtctcaaactgcctctgcaatgttc
Downstream sequence
ttcatgagattaattaagtgcgagaattaaatgaggtgagccgcgaacggggcctagcatagtgcggggcgcactcagcaggtgttgtttatAGGGATCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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