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VISDB
Viral Integration Site DataBase
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TVIS44010078
Basic Information
VIS ID
TVIS44010078
Fusion event
HTLV-1-CTNNA3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
67936201/66176443 (Hg38)
End
67936201/66176443 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
CTNNA3
miRNAs that regulate target gene
hsa-mir-182-5p
;
hsa-mir-5704
;
hsa-mir-4470
;
hsa-mir-3065-5p
;
hsa-mir-3613-3p
;
hsa-mir-1295b-3p
;
hsa-mir-15a-3p
;
hsa-mir-4717-5p
;
hsa-mir-6826-3p
;
hsa-mir-6891-3p
;
hsa-mir-6072
;
hsa-mir-6795-3p
;
hsa-mir-6887-3p
;
hsa-mir-548ay-3p
;
hsa-mir-548at-3p
;
hsa-mir-548as-3p
;
hsa-mir-548t-3p
;
hsa-mir-548ap-3p
;
hsa-mir-548aa
;
hsa-mir-548x-3p
;
hsa-mir-548j-3p
;
hsa-mir-548aq-3p
;
hsa-mir-548am-3p
;
hsa-mir-548aj-3p
;
hsa-mir-548ah-3p
;
hsa-mir-548ae-3p
Nearest miRNA
hsa-mir-1265/Upstream/2803395; hsa-mir-107/Downstream/1226908;
Nearest TSS
ENST00000439456/Upstream/97200;
ENST00000472278/Downstream/749563;
Nearest CpG islands
None/Target,
chr10-CpG: 68/Upstream/1122140
,
chr10-CpG: 39/Downstream/1587642
Nearest cancer related gene
CTNNA3
(TSG, No orient, 0)
Upstream sequence
TGTTCTGACCTTATGTATTTGAAATATTTTTAAATTACTGAAGTCTTTGGAAACTGCAAATAGTTTCTTATGAAAAAAGATGCTCTTACATAAAAGGAAC
Downstream sequence
TATTAAACTTAGAGAATTGAACAATGGAGAGATCAGATAGTAACTTACTATTCTTTAAAAGTCTTAAATATATGTAAAATTCACAAAAATTCACAAAAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Sample Information
×
Sample name
ATL188
Sample type
Nontumor
Gender
Female
CpG Island Information
×
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