Basic Information
VIS ID
TVIS44010079
Fusion event
HTLV-1-HK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
71092484/69332728 (Hg38)
End
71092484/69332728 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
HK1
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-1296-5p ; hsa-mir-615-3p ; hsa-mir-99b-5p ; hsa-mir-23b-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-93-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-1265/Upstream/1929318; hsa-mir-107/Downstream/2458019;
Nearest TSS
ENST00000439456/Upstream/13875; ENST00000494253/Downstream/5292;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/13107, chr10-CpG: 47/Downstream/75921
Upstream sequence
agcctcccaaagtgctgggattacaggtgtcagccattgtacctggcctggcctctgtttcatctgtcagataaggtaaatgattcctgccttgttctct
Downstream sequence
gcccccacttttcaaatgagagaatggacgaggaaatacttggaaagtgtacacaactgtacaaatgccaggtgttatcattgtCACTCACCCAGCTCAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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