Basic Information
VIS ID
TVIS44010082
Fusion event
HTLV-1-LOC105378477 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
110208699/108448941 (Hg38)
End
110208699/108448941 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
LOC105378477
Nearest miRNA
hsa-mir-107/Upstream/4180536; hsa-mir-202/Downstream/2449149;
Nearest TSS
ENST00000439456/Upstream/251092; ENST00000421481/Downstream/112874;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/533735, chr10-CpG: 63/Downstream/17228
Nearby gene
LINC01435(No orient, 379648)
Upstream sequence
AGAGCCAATGGCAGTGTTCTCCATTACTCTTCATCCTTCACCGGTATTTTTGTTTATTACCACTCAAAATGCTCAATCAGTCCCCAACTGAGAAAAATCC
Downstream sequence
CTACCTTGAGGAGTACACAAATATTTTTGGATAAAGCAAGTGGCTTCCTCATATAAAGAGGTCTGGGTTTTTTAGCTTCATTTTTTCTGGAAGTAACTAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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