Basic Information
VIS ID
TVIS44010084
Fusion event
HTLV-1-CPXM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.13
Reference genome
GRCh37/hg19
Start
125536867/123777351 (Hg38)
End
125536867/123777351 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
CPXM2
miRNAs that regulate target gene
hsa-mir-6751-3p ; hsa-mir-4762-3p ; hsa-mir-6873-3p ; hsa-mir-4539 ; hsa-mir-4695-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-6787-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-6877-3p ; hsa-mir-6819-3p
Nearest miRNA
hsa-mir-107/Upstream/1360284; hsa-mir-202/Downstream/1255432;
Nearest TSS
ENST00000439456/Upstream/681; ENST00000487190/Downstream/109815;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/110225, chr10-CpG: 25/Downstream/80190
Upstream sequence
TCCACCCATATCACACTGTCTACATATGGGCCATCAGCCAGTACTTCCTGGGCATTTGGGACCTGACAACACTGTGCCCAAACCAAAGTAGGTCATTAAC
Downstream sequence
CTTGTCCTCAAAATCACTTCTTCCTTTTCTCCACAGAAGCACACCAGGCCTCTCTCTCTCCCCAACTCACTCCAACGGGTGACCTCCACTGGGCAGCCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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