Basic Information
VIS ID
TVIS44010127
Fusion event
HTLV-1-FRMD6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
52074777/51608059 (Hg38)
End
52074777/51608059 (Hg38)
Orient
+
Location type
Intronic
Target gene
FRMD6
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-101-3p ; hsa-mir-5197-3p ; hsa-mir-17-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-642a-5p ; hsa-mir-3124-3p ; hsa-mir-130b-5p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-3123 ; hsa-mir-141-5p
Nearest miRNA
hsa-mir-208a/Upstream/1308113; hsa-mir-1185-1/Downstream/2340368;
Nearest TSS
ENST00000550708/Upstream/8107; ENST00000554778/Downstream/29888;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/367278, chr14-CpG: 154/Downstream/43198
Upstream sequence
GGAAGCGGAGTCGTCTTACTGTAATTATTTGAGGCTCTGGGCAGTTTTCTGTGCATCAGATCCAGTAACACAAAACAGAAGAAAACCATTATTCCCAAAC
Downstream sequence
CCAGCTATTTACTCTCTCCCACACAGCTTTTTCTGGGAAAAGGAGACTGCGGTGATTTGGGAGAGGGAGCTGTGCAATCCCCAGCTAGGAGCCTACGAGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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