Basic Information
VIS ID
TVIS44010148
Fusion event
HTLV-1-TMEM101 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
42097035/44019667 (Hg38)
End
42097035/44019667 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM101
miRNAs that regulate target gene
hsa-mir-125a-5p ; hsa-mir-10a-5p ; hsa-mir-320a ; hsa-mir-218-5p ; hsa-mir-3686 ; hsa-mir-4473 ; hsa-mir-6820-3p ; hsa-mir-3164 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-142-3p ; hsa-mir-6073 ; hsa-mir-3934-3p ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p ; hsa-mir-6505-3p ; hsa-mir-617 ; hsa-mir-3182 ; hsa-mir-20b-3p ; hsa-mir-3137 ; hsa-mir-5588-5p ; hsa-mir-4799-3p ; hsa-mir-4720-5p ; hsa-mir-4251 ; hsa-mir-8073 ; hsa-mir-221-5p ; hsa-mir-4324 ; hsa-mir-4319 ; hsa-mir-125b-5p ; hsa-mir-331-3p ; hsa-mir-3607-5p ; hsa-mir-4501 ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-512-3p ; hsa-mir-10b-5p ; hsa-mir-504-5p ; hsa-mir-1273d
Nearest miRNA
hsa-mir-1180/Upstream/574782; hsa-mir-10226/Downstream/188104;
Nearest TSS
ENST00000595228/Upstream/220; ENST00000585962/Downstream/3439;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/4603, chr17-CpG: 51/Downstream/46619
Upstream sequence
gattgaaatagagatttatctgaaacagcgctggatgaatgcctcaaggggctcacacaacctgttccgggacttggtgaccattgtttgtgtccatgtt
Downstream sequence
caattgagttcaaatttaatatttaacttttcctccacatttggcctcaatctgatactcaactgtaggaaaatactcttacggatacacagggaagcca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate