Basic Information
VIS ID
TVIS44010161
Fusion event
HTLV-1-DCC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
50679168/53152798 (Hg38)
End
50679168/53152798 (Hg38)
Orient
-
Location type
Intronic
Target gene
DCC
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-889-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-4696 ; hsa-mir-6500-3p ; hsa-mir-5092 ; hsa-mir-1255b-2-3p ; hsa-mir-6738-3p ; hsa-mir-3678-3p ; hsa-mir-544a ; hsa-mir-513b-5p ; hsa-mir-2467-3p ; hsa-mir-298 ; hsa-mir-17-3p ; hsa-mir-1205 ; hsa-mir-1184 ; hsa-mir-3158-5p ; hsa-mir-6847-5p ; hsa-mir-4719 ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-219a-2-3p
Nearest miRNA
hsa-mir-1-2/Upstream/3026235; hsa-mir-122/Downstream/84303;
Nearest TSS
ENST00000575820/Upstream/211869; ENST00000579941/Downstream/238986;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/810446, chr18-CpG: 59/Downstream/1071601
Nearest cancer related gene
DCC(TSG, No orient, 0)
Upstream sequence
GGAGATTAGGCCTCCAAGAGCAAAGAAAAGAAGTCCTGATTGGTTCTTTATTGAGACCTTATTTGAAGGCAAGTTACTGTTGAGAGAAAGCATGGAGGAT
Downstream sequence
TAGTAAGAACAAAATTAATTCCCCTGTATAAGATAAGAAGCCATTCCTTTGTTAAAACTGTGTTCCTCCGTTTTAATATAACGCCTGTTTAAACTGAGGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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