Basic Information
VIS ID
TVIS44010175
Fusion event
HTLV-1-CNTNAP5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
125295489/124537912 (Hg38)
End
125295489/124537912 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
CNTNAP5
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-210-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-190a-3p ; hsa-mir-1277-5p ; hsa-mir-4789-5p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-466 ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-16-1-3p ; hsa-mir-1285-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-3680-5p ; hsa-mir-4798-3p ; hsa-mir-5580-3p ; hsa-mir-4643 ; hsa-mir-4789-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/10816544; hsa-mir-10b/Downstream/2885625;
Nearest TSS
ENST00000437798/Upstream/316207; ENST00000430692/Downstream/1173057;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/512234, chr2-CpG: 51/Downstream/2118208
Upstream sequence
TTTTACAAGAAAAGTGGATCATTATCTTGATGAAATGGTCCTTCTCCACCTGTGCATATGGACGGGCACAAAAGAGCCTTTATTCATGGAAAACACGGAG
Downstream sequence
GGCTGAGCAAGCCAGGTTGGCACTTCATTTTGGCCCACCAGACGGTGGTGAGAATCCTTCCCCACCAACTGGTAATCTGACATATTGATGCTGAAAACGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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