Basic Information
VIS ID
TVIS44010181
Fusion event
HTLV-1-PDE1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
183263520/182398793 (Hg38)
End
183263520/182398793 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
PDE1A
miRNAs that regulate target gene
hsa-mir-133b ; hsa-mir-133a-3p ; hsa-mir-5587-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-3691-3p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-1264
Nearest miRNA
hsa-mir-10b/Upstream/1093141; hsa-mir-1244-1/Downstream/1980182;
Nearest TSS
ENST00000437798/Upstream/156730; ENST00000469118/Downstream/28238;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/506001, chr2-CpG: 53/Downstream/317173
Upstream sequence
TTGATTACACTTAAAGTGTAGGAGCATACCGCTATCTTAAATCTTACTAGTTTTTTCATTTTTGCCTTCTTATAATTAATTCATACAAATGGCTTGAATC
Downstream sequence
CTGTAGATACTTTACTTTTAGAAATCTTAAAtttcttttttaaaatttattttactttaagttccagaatacatgtggagaatgtgcaagtttgttacat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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