Basic Information
VIS ID
TVIS44010182
Fusion event
HTLV-1-chr2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
191435757/190571031 (Hg38)
End
191435757/190571031 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105376748 ; NEMP2
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-19a-5p ; hsa-mir-19b-1-5p ; hsa-mir-19b-2-5p ; hsa-mir-2052 ; hsa-mir-30a-3p ; hsa-mir-30d-3p ; hsa-mir-30e-3p ; hsa-mir-4277 ; hsa-mir-449b-3p ; hsa-mir-562 ; hsa-mir-5697 ; hsa-mir-584-3p
Nearest miRNA
hsa-mir-10b/Upstream/1437920; hsa-mir-1244-1/Downstream/16212203;
Nearest TSS
ENST00000437798/Upstream/36176; ENST00000423376/Downstream/75715;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/36015, chr2-CpG: 149/Downstream/77189
Nearby gene
NEMP2(No orient, 36289)
Upstream sequence
TAAGGAAGACCAGTTAGCAAATTTATTGTTTGGAGTCCCGATTACATATTTTTGTTGGATTTATTAATGATTTAGGCACTGTGGatagagggtaaaaact
Downstream sequence
cagattctgaagctgattgcctggcttccatccattagctgtgtgaccttgggaaagttgcttgaatgctctgtgccttagttttattttctgtgagatg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate