Basic Information
VIS ID
TVIS44010190
Fusion event
HTLV-1-CYYR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
27915121/26542802 (Hg38)
End
27915121/26542802 (Hg38)
Orient
+
Location type
Intronic
Target gene
CYYR1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-629-3p ; hsa-mir-6867-3p ; hsa-mir-4286 ; hsa-mir-4713-5p ; hsa-mir-4666a-3p ; hsa-mir-7849-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-130b-5p ; hsa-mir-3156-5p ; hsa-mir-5692a
Nearest miRNA
hsa-let-7c/Upstream/968758; hsa-mir-3197/Downstream/411159;
Nearest TSS
ENST00000624081/Upstream/82588; ENST00000426771/Downstream/30374;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/371912, chr21-CpG: 61/Downstream/29889
Upstream sequence
agattttttttacatagaaaatcctaatcaatgtataaagtaattactagatgtacaaagtgaatttagcaatgttgttttatatatgatcaatacacta
Downstream sequence
acaccaattgtattttcatactctgcagcaacaaacaactagaaaacaaaattaataacaattccatgtattagggtgttaagaagcaaattactattta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate