Basic Information
VIS ID
TVIS44010195
Fusion event
HTLV-1-TBC1D5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
17491693/17450201 (Hg38)
End
17491693/17450201 (Hg38)
Orient
+
Location type
Intronic
Target gene
TBC1D5
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-493-5p ; hsa-mir-4446-5p ; hsa-mir-3679-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-655-5p ; hsa-mir-361-3p ; hsa-mir-329-5p ; hsa-mir-6779-3p
Nearest miRNA
hsa-mir-12127/Upstream/516941; hsa-let-7g/Downstream/1864647;
Nearest TSS
ENST00000440867/Upstream/43481; ENST00000449613/Downstream/173712;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/564851, chr3-CpG: 58/Downstream/292369
Upstream sequence
ggacccccagcaaactccagcagaattgcagaagaggggcctgactgttagaaagtaaactaacaaacagaaagctataacatcaacatcaacaaaaagg
Downstream sequence
acacccacgcaaaaaccccatccaaaagtcatcaacatcaaagataaaaggtagataaatccacgaagataaggaaaaaacagcgcaaaaatgctgaaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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