Basic Information
VIS ID
TVIS44010237
Fusion event
HTLV-1-TNIP3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q27
Reference genome
GRCh37/hg19
Start
122087191/121166036 (Hg38)
End
122087191/121166036 (Hg38)
Orient
-
Location type
Intronic
Target gene
TNIP3
miRNAs that regulate target gene
hsa-mir-142-3p ; hsa-mir-4261 ; hsa-mir-502-3p ; hsa-mir-501-3p ; hsa-mir-4496 ; hsa-mir-5580-3p ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-4325 ; hsa-mir-551b-5p ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-4666a-3p ; hsa-mir-338-5p ; hsa-mir-5089-5p ; hsa-mir-6807-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6778-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-150-5p ; hsa-mir-6747-3p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-1295b-3p ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-122-5p ; hsa-mir-129-5p ; hsa-mir-323a-5p ; hsa-mir-3650 ; hsa-mir-3911 ; hsa-mir-504-3p ; hsa-mir-6127 ; hsa-mir-7847-3p ; hsa-mir-876-3p
Nearest miRNA
hsa-mir-12113/Upstream/6509182; hsa-mir-1305/Downstream/4341223;
Nearest TSS
ENST00000502981/Upstream/1696; ENST00000424958/Downstream/50591;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/93065, chr4-CpG: 67/Downstream/214376
Upstream sequence
GAATATTTTTCTTCTGAAACATACCATGCACATACACACTCCATAGTTTTATATAGTGTAAGGTTCTCTTCAGCTTTAACTTTGTATTTGTATAGGGATG
Downstream sequence
TGGTAACATTGACCTAGAAAAGTGGGTGGGAAGAACATTTTCTTGCCAGGAAATACCATCCTTGGCATTGTGCCTCTTGAGTCTCCCCTGTAAAATATCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate