Basic Information
VIS ID
TVIS44010277
Fusion event
HTLV-1-ASCC3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q16.3
Reference genome
GRCh37/hg19
Start
101088323/100640447 (Hg38)
End
101088323/100640447 (Hg38)
Orient
+
Location type
Intronic
Target gene
ASCC3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-98-5p ; hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-1226-3p ; hsa-mir-425-5p ; hsa-let-7f-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-10398/Upstream/1515751; hsa-mir-1202/Downstream/6143678;
Nearest TSS
ENST00000381078/Upstream/130139; ENST00000565695/Downstream/240854;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/170800, chr6-CpG: 68/Downstream/240424
Upstream sequence
TATTCAAAGAGACCCTGGAATCATTGAGGTTACTTTGTATATGTCTAATATCAACTGAGATGTTATGGTGGTACATTTATTGTTTTTAAAATTGTAGTCA
Downstream sequence
GAACTCAGCTAATTATATAAATAGGGTGATACATTCTTGGTCATTTGGCAGACAAAAGATAAAATGAACATTGAAATAGAATGTTAACGCAAGTTAAGAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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