Basic Information
VIS ID
TVIS44010300
Fusion event
HTLV-1-GATA4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
11573950/11716441 (Hg38)
End
11573950/11716441 (Hg38)
Orient
-
Location type
Intronic
Target gene
GATA4
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-200b-3p ; hsa-mir-26b-5p ; hsa-mir-34a-5p ; hsa-mir-200c-3p
Nearest miRNA
hsa-mir-124-1/Upstream/681139; hsa-mir-10400/Downstream/1002691;
Nearest TSS
ENST00000518652/Upstream/8128; ENST00000526021/Downstream/40052;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/6027, chr8-CpG: 30/Downstream/33366
Nearest cancer related gene
GATA4(TSG, No orient, 0)
Upstream sequence
GTGTTTATGGATGCACAGGAAAACTGCTTTAAGGCATAAGTTGTTTTTTATTAAATTTGTCTTTTACCTATTCTTTTACAATTTTGGGGGTTTTCCTTTA
Downstream sequence
TGCTCAAGCTTCCTCAAGATTCTTCAAGGCAGATCAAAACCATCCTCAGTGGCAATCCTGTATTTGGCTTTTGATTTTGCTTATTTCACAGGAGGTTGCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate