Basic Information
VIS ID
TVIS44010300
Fusion event
HTLV-1-GATA4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
End
11573950/11716441 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-124-1/Upstream/681139; hsa-mir-10400/Downstream/1002691;
Nearest cancer related gene
GATA4(TSG, No orient, 0)
Upstream sequence
GTGTTTATGGATGCACAGGAAAACTGCTTTAAGGCATAAGTTGTTTTTTATTAAATTTGTCTTTTACCTATTCTTTTACAATTTTGGGGGTTTTCCTTTA
Downstream sequence
TGCTCAAGCTTCCTCAAGATTCTTCAAGGCAGATCAAAACCATCCTCAGTGGCAATCCTGTATTTGGCTTTTGATTTTGCTTATTTCACAGGAGGTTGCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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