Basic Information
VIS ID
TVIS44010303
Fusion event
HTLV-1-PRKDC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
48734021/47821460 (Hg38)
End
48734021/47821460 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRKDC
miRNAs that regulate target gene
hsa-mir-101-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-124-1/Upstream/4925185; hsa-mir-10400/Downstream/13893328;
Nearest TSS
ENST00000518652/Upstream/37321; ENST00000520994/Downstream/43332;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/56912, chr8-CpG: 28/Downstream/9820
Upstream sequence
TGTAGTCATACTAGGAATGTTAATATTTATTTTAAAATGCATTGCATTCACTTTGAAAAGATGATTAGCTAAAAGTGATAAGAGATTTAACAATACTATG
Downstream sequence
GGGTTTGTAGGTGGACTCAGGTCATGCAATTCCCTAGTGCTTCACAAGTACTACCTGTTTTTGAAATGTTTTAAACAATTTTGTTAAGTAGAAAACACCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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