Basic Information
VIS ID
TVIS44010306
Fusion event
HTLV-1-PDE7A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
66726189/65813954 (Hg38)
End
66726189/65813954 (Hg38)
Orient
+
Location type
Intronic
Target gene
PDE7A
miRNAs that regulate target gene
hsa-mir-409-3p ; hsa-mir-6807-5p ; hsa-mir-210-5p ; hsa-mir-203a-3p ; hsa-mir-345-3p ; hsa-mir-640 ; hsa-mir-1224-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-7977 ; hsa-mir-383-3p ; hsa-mir-6871-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-1-5p ; hsa-mir-221-5p ; hsa-mir-3672 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4461 ; hsa-mir-4767 ; hsa-mir-4768-3p ; hsa-mir-4786-5p ; hsa-mir-4793-5p ; hsa-mir-5186 ; hsa-mir-6087 ; hsa-mir-6089 ; hsa-mir-6502-3p ; hsa-mir-6864-3p ; hsa-mir-6888-5p ; hsa-mir-769-5p ; hsa-mir-8073
Nearest miRNA
hsa-mir-124-1/Upstream/1434697; hsa-mir-10400/Downstream/8734589;
Nearest TSS
ENST00000518652/Upstream/24870; ENST00000607622/Downstream/24794;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/168676, chr8-CpG: 128/Downstream/27400
Upstream sequence
AACCTTGATAATTTTCTCTTCTTCAACTGTCAATAGCTTTGAGTTCTTTAATATCACACCCATGAACTTCATAAACACCTGCATATTTTGCAAGTTGAGC
Downstream sequence
AATTTCAGTTTGCAAATGATTTTATTCTCTTTTATTAAAATTGCTAATAAATGGTCAGGAGCAACATTTGAGTGCAAACTAATTTTAAAAGTGGTATTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate