Basic Information
VIS ID
TVIS44010346
Fusion event
HTLV-1-chr18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
18520326/20940365 (Hg38)
End
18520326/20940365 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3156-2/Upstream/6110123; hsa-mir-1-2/Downstream/743153;
Nearest TSS
ENST00000575820/Upstream/5775898; ENST00000579454/Downstream/14505;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/5609190, chr18-CpG: 113/Downstream/170614
Nearby gene
ROCK1(+9375) ;
Nearest cancer related gene
ROCK1(OG, +9375) ;
Upstream sequence
gtagtttttatgggaagatatttccttttccaccataggcctgaaagcgctcgaaatgtccacttccagatactacagaaagagtgtttcaaacctgctc
Downstream sequence
tatgaaagggaatgttTTATATTTGTATGTATCATATGCCAATTGTTACCTTTTTTGGCAGCACTGAAAATTCAGGTGATCTTAAACATcagacagataa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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