Basic Information
VIS ID
TVIS44010354
Fusion event
HTLV-1-SPTSSA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
34902848/34433642 (Hg38)
End
34902848/34433642 (Hg38)
Orient
+
Location type
UTR3
Target gene
SPTSSA
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-454-3p ; hsa-mir-580-5p ; hsa-mir-6509-5p ; hsa-mir-331-5p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-3613-3p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-196b-5p ; hsa-mir-196a-5p ; hsa-mir-510-3p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-4738-3p ; hsa-mir-5583-5p ; hsa-mir-3129-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-208a/Upstream/3418900; hsa-mir-1185-1/Downstream/2518667;
Nearest TSS
ENST00000550708/Upstream/205828; ENST00000554608/Downstream/28714;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/372889, chr14-CpG: 34/Downstream/28771
Upstream sequence
TTCTCACTACTCCTATCTAATTGTGGTATCAATTGGCTCTAAAAATATTAAACACATATATATTACTTGAGACCTCTAGACTATAAAATACTTCAAAAGT
Downstream sequence
CTAGTCCTTAAAACGTAGGGCAAAAAATACCTCAATTTTggccgggcgcggtggctcacgcctgtaaacccagcactttgggaggccgaggcaggtggat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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