Basic Information
VIS ID
TVIS44010360
Fusion event
HTLV-1-PRRC2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.33
Reference genome
GRCh37/hg19
Start
31594695/31626918 (Hg38)
End
31594695/31626918 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
PRRC2A
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-1303 ; hsa-mir-1180-3p ; hsa-mir-760 ; hsa-mir-877-3p ; hsa-mir-744-5p ; hsa-mir-423-5p ; hsa-mir-330-5p ; hsa-mir-296-3p ; hsa-mir-93-3p ; hsa-mir-615-3p ; hsa-mir-92b-3p ; hsa-mir-18a-3p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-222-3p ; hsa-mir-106a-5p ; hsa-mir-25-3p ; hsa-let-7e-5p ; hsa-let-7c-5p ; hsa-mir-218-5p ; hsa-mir-4316 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-6825-5p ; hsa-mir-3144-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-7106-5p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-874-5p ; hsa-mir-765 ; hsa-mir-3202 ; hsa-mir-6089 ; hsa-mir-5008-5p ; hsa-mir-3179 ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-6783-5p ; hsa-mir-4779 ; hsa-mir-6753-5p ; hsa-mir-556-3p ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-605-5p
Nearest miRNA
hsa-mir-3143/Upstream/271602; hsa-mir-10398/Downstream/6869;
Nearest TSS
ENST00000381078/Upstream/1164; ENST00000483470/Downstream/1722;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/5671, chr6-CpG: 22/Downstream/4824
Upstream sequence
GAGGAAGATGGGCGAGACTCTGATGAGGAGGGTGCTGAGGGCCAGTGAGTTAGGGCCATCAGGGGAGAAGAGGAGGGGGTCTTGGTTTGTATTTTGGTAA
Downstream sequence
TATACTCTTAGAGGAGTATATTAGTTGCAGCTGATTTTAATTTCACTGTTGATCTGCTCACAGCAGGGATTCCCAATCAGCTTCTGGTGAGGAACGGCCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate