Basic Information
VIS ID
TVIS44010387
Fusion event
HTLV-1-WRN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
30989092/31131576 (Hg38)
End
30989092/31131576 (Hg38)
Orient
-
Location type
Intronic
Target gene
WRN
miRNAs that regulate target gene
hsa-mir-592 ; hsa-mir-597-5p ; hsa-mir-3681-3p ; hsa-mir-4717-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-4748 ; hsa-mir-329-5p ; hsa-mir-4464 ; hsa-mir-3664-5p ; hsa-mir-144-3p ; hsa-mir-224-5p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-4533 ; hsa-mir-1252-5p ; hsa-mir-3185 ; hsa-mir-4476 ; hsa-mir-6876-5p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4709-3p ; hsa-mir-6077 ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-5197-3p ; hsa-mir-4311 ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-4310 ; hsa-mir-7157-5p ; hsa-mir-3617-3p ; hsa-mir-216b-5p ; hsa-mir-5089-5p ; hsa-mir-4423-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-500b-3p ; hsa-mir-1295b-3p ; hsa-mir-3622a-5p ; hsa-mir-5582-5p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-7847-3p ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-3928-3p ; hsa-mir-5003-3p
Nearest miRNA
hsa-mir-124-1/Upstream/1174228; hsa-mir-10400/Downstream/10139472;
Nearest TSS
ENST00000518652/Upstream/11620; ENST00000524022/Downstream/45296;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/97867, chr8-CpG: 142/Downstream/507433
Upstream sequence
GACTGTCTTCTTGGTCTGGAAGAGCAGAGTTCTGCAGTAAAATAACAGGTCCCCCTTTTAGTAGACATCTCCATGTCTGCTGCTGGAACACATCAGTTTT
Downstream sequence
GTCTTAAGCCTCACTTCCAAATGTGCAGATGTGTCTGGTTCATTGATTGGCTGCCTGTCAAATTGAAACCTGATCTGCCTCATTGGCAAACCGTGCCCCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate