Basic Information
VIS ID
TVIS44010388
Fusion event
HTLV-1-TCEA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
54901115/53988555 (Hg38)
End
54901115/53988555 (Hg38)
Orient
+
Location type
Intronic
Target gene
TCEA1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-497-5p ; hsa-mir-20a-5p ; hsa-mir-3682-3p ; hsa-mir-1272 ; hsa-mir-5680 ; hsa-mir-5683 ; hsa-mir-889-3p ; hsa-mir-4480
Nearest miRNA
hsa-mir-124-1/Upstream/11092280; hsa-mir-10400/Downstream/7726233;
Nearest TSS
ENST00000518652/Upstream/43230; ENST00000519831/Downstream/33374;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/105974, chr8-CpG: 78/Downstream/33213
Upstream sequence
ACAAGTATGCCTTTTTTTTGAACTAAACATTTTATCTTTGATTCTCATTTTAAATATTAAGCAATATTTTTAATAGAGAAAATACCCATTATAGCTCAGT
Downstream sequence
ACAATAAATGAAAAGCAATGATCTTGGTATAAGGAGAGGGATGAAGGGATGGGACCAGAGAATGACAGCtttcttttttgagacggagtcttgctctgtc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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