Basic Information
VIS ID
TVIS44010397
Fusion event
HTLV-1-AP4S1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
31512732/31043526 (Hg38)
End
31512732/31043526 (Hg38)
Orient
-
Location type
Intronic
Target gene
AP4S1
miRNAs that regulate target gene
hsa-mir-15b-5p ; hsa-mir-5010-3p ; hsa-mir-4713-5p ; hsa-mir-4693-5p ; hsa-mir-4711-3p ; hsa-mir-4703-3p ; hsa-mir-3650 ; hsa-mir-7157-3p ; hsa-mir-6737-3p ; hsa-mir-5008-3p ; hsa-mir-2116-3p ; hsa-mir-4259 ; hsa-mir-4715-5p ; hsa-mir-892a ; hsa-mir-4318
Nearest miRNA
hsa-mir-208a/Upstream/28784; hsa-mir-1185-1/Downstream/5908783;
Nearest TSS
ENST00000550708/Upstream/16883; ENST00000556480/Downstream/22770;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/16676, chr14-CpG: 167/Downstream/163279
Upstream sequence
GTAGAATGGAACAGGTACAGGAAGAACAGGTTTCTTGAAGTCAAATTTCAGTAATCTTAGGACTGTAGTAGGGAGAATCTGTTGGGAAGAGAATCTTACC
Downstream sequence
TACACTGGAGAGTAGGATGAGGAGAGAAAGGAGGTTCTGGagtgtttcacattttccttatctcatttagccctcacaataactcggcaacagagttaac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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