Basic Information
VIS ID
TVIS44010407
Fusion event
HTLV-1-LRP8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
53775501/53309829 (Hg38)
End
53775501/53309829 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
LRP8
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-19b-3p ; hsa-mir-30b-5p ; hsa-mir-4789-5p ; hsa-mir-377-3p ; hsa-mir-374a-5p ; hsa-mir-190a-3p ; hsa-mir-3119 ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4789-3p
Nearest miRNA
hsa-mir-12136/Upstream/1473427; hsa-mir-101-1/Downstream/744250;
Nearest TSS
ENST00000473358/Upstream/5293; ENST00000445039/Downstream/17570;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/25636, chr1-CpG: 192/Downstream/16186
Upstream sequence
agataaaggtggtgaaagctgtgcccctgctctcaggATGGATTCCACCTCCGACTCCTCTCAGCTGTCCCCAGGGCACCCAGCCCAGCCCTGGCACGGG
Downstream sequence
GCAGGCACACCTTCATTTATCATCAGTGATCGCCGTTATTCATATGAATGGGAGGATGCTTCTGAGCAGAACCAACTTTGAGCAGCAGCAGAAAGGAAGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate