Basic Information
VIS ID
TVIS44010408
Fusion event
HTLV-1-C1orf87 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p32.1
Reference genome
GRCh37/hg19
Start
60484850/60019178 (Hg38)
End
60484850/60019178 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
C1orf87
miRNAs that regulate target gene
hsa-mir-6719-3p ; hsa-mir-4526 ; hsa-mir-3660 ; hsa-mir-6730-3p ; hsa-mir-301b-5p ; hsa-mir-301a-5p ; hsa-mir-1234-3p ; hsa-mir-7107-5p ; hsa-mir-6777-3p ; hsa-mir-22-3p ; hsa-mir-4714-5p
Nearest miRNA
hsa-mir-12136/Upstream/285882; hsa-mir-101-1/Downstream/1826897;
Nearest TSS
ENST00000473358/Upstream/8224; ENST00000456878/Downstream/54558;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/92267, chr1-CpG: 23/Downstream/54465
Upstream sequence
aAtgatatggtttggctctgtgtccccacccaaatctaatgtcaaactgtattctccatgtgttgaaggaggggcctggtggcaggtgattggatcatgg
Downstream sequence
gggcagatttccctcatgctgttctcatgatagttttcacgagatctgatagtttaaaagtgtggcacgtccccctcactgtctcttcctctctcctgct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate