Basic Information
VIS ID
TVIS44010430
Fusion event
HTLV-1-DUSP16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
12645230/12492296 (Hg38)
End
12645230/12492296 (Hg38)
Orient
-
Location type
Intronic
Target gene
DUSP16
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-192-5p ; hsa-mir-6818-5p ; hsa-mir-580-3p ; hsa-mir-4693-5p ; hsa-mir-4738-3p ; hsa-mir-892a ; hsa-mir-4318 ; hsa-mir-606
Nearest miRNA
hsa-mir-1244-3/Upstream/380260; hsa-let-7i/Downstream/272353;
Nearest TSS
ENST00000382841/Upstream/6943; ENST00000540224/Downstream/13891;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/134802, chr12-CpG: 111/Downstream/69403
Upstream sequence
cagtccattcactttttctctttcccatatgccattctgtttccctttttcttcaaactccctatatgtccccactcatcttcactcacagctgaagaat
Downstream sequence
gaccttgcttcctactacaatggaaaaactgaaacagtcagaggcaaattttgatagacttccatcaccacatttacccatctctcagcaaatgcgccca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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