Basic Information
VIS ID
TVIS44010438
Fusion event
HTLV-1-WDFY2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
52322960/51748824 (Hg38)
End
52322960/51748824 (Hg38)
Orient
+
Location type
Intronic
Target gene
WDFY2
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-19b-3p ; hsa-mir-2355-3p ; hsa-mir-3942-3p ; hsa-mir-676-3p ; hsa-mir-6749-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-5100 ; hsa-mir-124-5p ; hsa-mir-6852-3p ; hsa-mir-4437 ; hsa-mir-3909 ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-1224-3p ; hsa-mir-186-3p ; hsa-mir-545-3p ; hsa-mir-10b-3p ; hsa-mir-4255 ; hsa-mir-24-3p
Nearest miRNA
hsa-mir-15a/Upstream/196157; hsa-mir-1267/Downstream/1061226;
Nearest TSS
ENST00000623511/Upstream/9676; ENST00000618844/Downstream/25300;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/163725, chr13-CpG: 96/Downstream/54861
Upstream sequence
AGGTAAAGAACATCCTTTCACATTGTAGGCATTAATCAGTAAAGTAAGGAAGCAAGCCATCAAAACTGAGGGAACTTAGCCAAAATTGTAATGCATCTTA
Downstream sequence
TACCTTTTTTTCAGACTAAAGTATTATAAGCCAAAGCAAGTAAAACTGACTTTCCAAGTTTTGTCCTTCATTTTTCTCTTTCATATTCCAGAACAAATAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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