Basic Information
VIS ID
TVIS44010451
Fusion event
HTLV-1-CDC27 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
45213986/47136620 (Hg38)
End
45213986/47136620 (Hg38)
Orient
-
Location type
Intronic
Target gene
CDC27
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-32-5p ; hsa-mir-16-5p ; hsa-mir-223-3p ; hsa-mir-539-5p ; hsa-mir-4470 ; hsa-mir-491-3p ; hsa-mir-4275 ; hsa-mir-767-5p ; hsa-mir-502-3p ; hsa-mir-501-3p ; hsa-mir-497-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-3148 ; hsa-mir-3917 ; hsa-mir-590-3p ; hsa-mir-4282 ; hsa-mir-548c-3p ; hsa-mir-3074-5p ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-548v ; hsa-mir-187-5p ; hsa-mir-1283 ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-944 ; hsa-mir-10a-3p ; hsa-mir-1253 ; hsa-mir-5579-5p ; hsa-mir-5197-3p ; hsa-mir-4311 ; hsa-mir-5583-3p ; hsa-mir-5701 ; hsa-mir-5588-5p ; hsa-mir-4799-3p ; hsa-mir-4720-5p ; hsa-mir-6868-5p ; hsa-mir-3128 ; hsa-mir-3126-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-218-2-3p ; hsa-mir-27a-3p
Nearest miRNA
hsa-mir-1180/Upstream/163520; hsa-mir-10226/Downstream/896262;
Nearest TSS
ENST00000595228/Upstream/12725; ENST00000572193/Downstream/624;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/36231, chr17-CpG: 64/Downstream/52265
Upstream sequence
AATAAATGTCAACAGTAAGTATGGTGTTGAGGCAGAAATAGGACCAAACTTTTTCATATCTTATTCAGTTGATAACAATATGACCTAGGTAGTAATTTCC
Downstream sequence
TATGTGTCTACTTATACACAAGTACAAAAAAGTAAAATAGAGATACTGCTAAATAAAAGGGTACACTAAGTTCTTAATAGTAACTCAATAAACCAGAACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate