Basic Information
VIS ID
TVIS44010455
Fusion event
HTLV-1-ATP13A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
19763624/19652815 (Hg38)
End
19763624/19652815 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ATP13A1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-10395/Upstream/217657; hsa-let-7e/Downstream/746457;
Nearest TSS
ENST00000633603/Upstream/5104; ENST00000541458/Downstream/581;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/9117, chr19-CpG: 18/Downstream/1007
Upstream sequence
CGGGCCTGCGGACAGACAGGGGCACCCTCACCATCTGTCCCTCCCTCTGCCCACACTCTGCATTTCCTGAGCTCTGACCATGCGCTGGGAGCCAAGGGGA
Downstream sequence
CAATGGAAGGCCCTGTTCCCGTAGTGGGCACATGCGAGGGTTGGGAGGGGAGAAATGCCAGGAGGGTACCAGGCACGCTTGAGGGGTGGGATCTGGCAGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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