Basic Information
VIS ID
TVIS44010457
Fusion event
HTLV-1-VASP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
46011427/45508169 (Hg38)
End
46011427/45508169 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
VASP
miRNAs that regulate target gene
hsa-mir-610 ; hsa-mir-193b-3p ; hsa-mir-1-3p ; hsa-mir-330-5p ; hsa-mir-3615 ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-3679-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-6832-3p ; hsa-mir-361-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-4282 ; hsa-mir-3606-3p ; hsa-mir-4251 ; hsa-mir-2355-5p ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-6778-3p ; hsa-mir-3141 ; hsa-mir-199a-5p ; hsa-mir-199b-5p ; hsa-mir-214-3p ; hsa-mir-34a-3p ; hsa-mir-3617-3p ; hsa-mir-3619-5p ; hsa-mir-4291 ; hsa-mir-4302 ; hsa-mir-4468 ; hsa-mir-4676-5p ; hsa-mir-575 ; hsa-mir-609 ; hsa-mir-6748-5p ; hsa-mir-6759-5p ; hsa-mir-6772-5p ; hsa-mir-6793-5p ; hsa-mir-761 ; hsa-mir-922
Nearest miRNA
hsa-mir-10395/Upstream/71465; hsa-let-7e/Downstream/130825;
Nearest TSS
ENST00000633603/Upstream/659; ENST00000590459/Downstream/14387;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/135, chr19-CpG: 33/Downstream/9484
Upstream sequence
GGCAGCGACTCCCCGCAGGGATGCCAGGATTGAGGCAGGGCTCAGACTCTCCTCCCCCTCCCCCCAGACTTCAGCTCGAGGTCCGGGAAGGATTGTGGGG
Downstream sequence
GACCGATTTGGGATACCCTGGGACTTGGAAGAGAGACTGAGACTCAGACCCTGGGTGTGCAGGTCCCCCGTTTACTTGGTGCTGGAAAAAGTCTCCCCAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate