Basic Information
VIS ID
TVIS44010465
Fusion event
HTLV-1-INPP5D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q37.1
Reference genome
GRCh37/hg19
Start
233947337/233082627 (Hg38)
End
233947337/233082627 (Hg38)
Orient
-
Location type
Intronic
Target gene
INPP5D
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-mir-93-3p
Nearest miRNA
hsa-mir-10b/Upstream/532054; hsa-mir-149/Downstream/4428304;
Nearest TSS
ENST00000437798/Upstream/6365; ENST00000474278/Downstream/37975;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/22019, chr2-CpG: 41/Downstream/121650
Upstream sequence
CTTTCATTGTTTCTTAGTTTAGTAACTTTAGCTCTTTTCCTGGGGACTTCTGTTCTCTTGTCAACACCAAAGATCTCATCTTTGTTCTTTGCAGACCAAC
Downstream sequence
TTCATGGAGTTGGCCCACGTGTCATAGCCCATGACAGCCCTGTATCAATCAGGGAGAGGAGCTGCCTCACCTGGGGGACTCTTTTCTCTCACTCCATCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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