Basic Information
VIS ID
TVIS44010473
Fusion event
HTLV-1-BTD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
15649549/15608042 (Hg38)
End
15649549/15608042 (Hg38)
Orient
+
Location type
Intronic
Target gene
BTD
miRNAs that regulate target gene
hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-340-5p ; hsa-mir-4729 ; hsa-mir-10b-3p ; hsa-mir-664a-3p ; hsa-mir-6516-5p ; hsa-mir-1273e ; hsa-mir-6499-3p ; hsa-mir-4722-5p ; hsa-mir-2467-3p ; hsa-mir-1827 ; hsa-mir-219b-3p ; hsa-mir-4649-3p ; hsa-mir-1247-3p ; hsa-mir-4768-3p ; hsa-mir-4257 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-302f ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-3942-3p ; hsa-mir-5100 ; hsa-mir-4670-3p ; hsa-mir-6837-3p ; hsa-mir-3620-3p ; hsa-mir-5584-3p ; hsa-mir-148a-5p ; hsa-mir-7160-5p ; hsa-mir-6125 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-570-3p ; hsa-mir-367-5p ; hsa-mir-1267
Nearest miRNA
hsa-mir-12127/Upstream/111734; hsa-let-7g/Downstream/89256;
Nearest TSS
ENST00000440867/Upstream/5904; ENST00000482824/Downstream/21960;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/5968, chr3-CpG: 142/Downstream/250948
Upstream sequence
CTCATTAAATCTGTGGACTTCAGAGTACCAAAGCTCAGCAACAGGCTTGAAACAAACCCAGTGAAAAGCAACTTTATTATTGAGCTGAGGATTGATATCA
Downstream sequence
GTAATAACTCATTAATAAAAAAGCTTGATAATAAAAACTCCCAGTGCCTGATGCCAGCTGACAGACACTGGGAGTTTTCCCAGGTACCCTGTGACCTAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate