Basic Information
VIS ID
TVIS44010517
Fusion event
HTLV-1-HNF4G integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
76417189/75504954 (Hg38)
End
76417189/75504954 (Hg38)
Orient
-
Location type
Intronic
Target gene
HNF4G
miRNAs that regulate target gene
hsa-mir-129-5p ; hsa-mir-3149 ; hsa-mir-576-5p ; hsa-mir-4263 ; hsa-mir-4799-5p ; hsa-mir-30a-5p ; hsa-mir-194-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-124-1/Upstream/799207; hsa-mir-10400/Downstream/1461814;
Nearest TSS
ENST00000518652/Upstream/96918; ENST00000396423/Downstream/34915;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/96765, chr8-CpG: 59/Downstream/1177066
Nearby gene
HNF4G(+35014) ;
Upstream sequence
TGAATTGTGGAAACTACTGTGAATATCTAATCTGTTTCACTTTATAATGTTGTACTTTTGAATTATACCTATTATATTTGATGGGACAAGAGAGGAAAGA
Downstream sequence
TGAGTGAATATTTCTTAATTCCACTCATTAATATAGGTGATTATAGAAACTTCTACCAGAATCTGGGATATGCTCAATTTTTAACACTCATGAGTATCAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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