Basic Information
VIS ID
TVIS44010523
Fusion event
HTLV-1-DAPK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
90152487/87537572 (Hg38)
End
90152487/87537572 (Hg38)
Orient
+
Location type
Intronic
Target gene
DAPK1
miRNAs that regulate target gene
hsa-mir-214-3p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-124-3p ; hsa-mir-218-5p ; hsa-mir-1277-5p ; hsa-mir-448 ; hsa-mir-190a-3p ; hsa-mir-4671-3p ; hsa-mir-5011-5p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-5580-3p ; hsa-mir-130a-3p ; hsa-mir-376c-3p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-101-2/Upstream/3567715; hsa-let-7a-1/Downstream/1208264;
Nearest TSS
ENST00000422679/Upstream/38566; ENST00000463069/Downstream/101866;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/38670, chr9-CpG: 24/Downstream/121966
Nearest cancer related gene
DAPK1(TSG, No orient, 0)
Upstream sequence
ttgtatgtgtagtttggatgagatgtgcatgtgtgtagtatgtgacatacatggtgtatgtgtgtgtatgtggaatatggtgtgcatgtctggagtatct
Downstream sequence
ggcatgtgtgtagatgtgtagtgtgtgCGGCATACATGGTAAGTAGATATATGTATGTGGCATATATGATATGATCTGTGTGTGCGCGTTAGTGTGTCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate