VISDB - VIS Detail

Basic Information

VIS ID

TVIS44010532

Fusion event

HTLV-1-MAPK8IP3 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr16

Cytoband

p13.3

Reference genome

GRCh37/hg19

Start

1783949/1733948 (Hg38)

End

1783949/1733948 (Hg38)

Orient

Location type

Intronic

Target gene

MAPK8IP3

miRNAs that regulate target gene

hsa-mir-320a ; hsa-mir-5197-3p ; hsa-mir-6842-3p ; hsa-mir-6816-5p ; hsa-mir-3196 ; hsa-mir-3180-3p ; hsa-mir-3180 ; hsa-mir-4505 ; hsa-mir-5787 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-4467 ; hsa-mir-566 ; hsa-mir-5580-5p ; hsa-mir-8072 ; hsa-mir-3960 ; hsa-mir-6720-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-6504-5p ; hsa-mir-3064-5p ; hsa-mir-6875-3p ; hsa-mir-6778-3p ; hsa-mir-4778-3p ; hsa-mir-1248 ; hsa-mir-5088-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-1200 ; hsa-mir-378a-5p ; hsa-mir-1254 ; hsa-mir-1295b-3p ; hsa-mir-143-5p ; hsa-mir-15a-3p ; hsa-mir-194-3p ; hsa-mir-2861 ; hsa-mir-3116 ; hsa-mir-3202 ; hsa-mir-3919 ; hsa-mir-4493 ; hsa-mir-4533 ; hsa-mir-4717-5p ; hsa-mir-5008-5p ; hsa-mir-504-3p ; hsa-mir-5698 ; hsa-mir-5704 ; hsa-mir-6499-3p ; hsa-mir-6770-5p ; hsa-mir-6777-5p ; hsa-mir-6825-5p ; hsa-mir-6889-5p ; hsa-mir-8065 ; hsa-mir-874-5p

Nearest miRNA

hsa-mir-3176/Upstream/963671; hsa-mir-11401/Downstream/1037;

Nearest TSS

ENST00000527434/Upstream/19740; ENST00000568271/Downstream/10091;

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/27270, chr16-CpG: 34/Downstream/6344

Upstream sequence

TCTTGTCAGCGCTGCCACAACCAGGTCCTTCTGCCTGACCTGGCCCCAGCCATTCACTTCTTCTGGGCACACAGGACCTTTGGCACCGGCCGTGGGAGCA

Downstream sequence

ACGCCAGCAGCAGTGGCTGTGTGGTAGGGGCCTTCCCCAGCCACGGACCCCAGGAAGCCTCCATTTGTGAAACAGGACCCCTGCACCTCTGTGGGAGAGG

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.